Drug General Information (ID: DDIJ03T92F)
Drug Name			Dasatinib		Drug Info		Dexlansoprazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Proton Pump Inhibitors
Structure

Mechanism of Dasatinib-Dexlansoprazole Interaction (Severity Level: Major)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Dasatinib				Dexlansoprazole
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Dasatinib due to altered gastric pH caused by Dexlansoprazole

Recommended Action
Management		Concomitant use of dasatinib with H2-receptor antagonists or proton pump inhibitors is not recommended. If gastric acidity management is necessary, antacids should be considered in place of these agents. However, patients treated with dasatinib should avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) for at least two hours before and two hours after administration of dasatinib.

References
1	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.