Drug General Information (ID: DDIIX3GT18)
Drug Name			Isradipine		Drug Info		Atenolol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antihypertensive Agents
Structure

Mechanism of Isradipine-Atenolol Interaction (Severity Level: Moderate)
Increased risk of cardiac depression Click to Show/Hide Mechanism Graph
Drug Name		Isradipine				Atenolol
Mechanism		Cardiac depressant effects				Cardiac depressant effects
Key Mechanism Factor 1
		Factor Name		Cardiac depression
		Factor Description		Cardiac depression may manifest as negative heart rate, negative conduction, and negative contractility. Symptoms include: excessive or more than normal sleep, irritability, loss of interest in activities, and fatigue.
Mechanism Description		Increased risk of cardiac depression by the combination of Isradipine and Atenolol

Recommended Action
Management		Close clinical monitoring of patient hemodynamic response and tolerance is recommended if a calcium channel blocker is prescribed with a beta blocker, and the dosage of one or both agents adjusted as necessary. The same precaution should be observed when beta blocker ophthalmic solutions are used, since they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels.

References
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