Drug General Information (ID: DDIISFQC78)
Drug Name			Bupivacaine		Drug Info		Tilmanocept		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anesthetics				Diagnostic Radiopharmaceuticals

Mechanism of Bupivacaine-Tilmanocept Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Bupivacaine				Tilmanocept
Mechanism		Reduce lymphatic flow of Technetium Tc 99m tilmanocept				Technetium Tc 99m tilmanocept
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Tilmanocept when combined with Bupivacaine

Recommended Action
Management		Co-injection (mixture) of local anesthetics with Technetium Tc 99m tilmanocept is not recommended due to potential impairment of lymph nodal mapping.

References
1	Product Information. Lymphoseek (tilmanocept). Navidea Biopharmaceuticals, Dublin, OH.