Drug General Information (ID: DDIIPWD6OZ)
Drug Name			Isocarboxazid		Drug Info		Dextroamphetamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Cns Stimulants
Structure

Mechanism of Isocarboxazid-Dextroamphetamine Interaction (Severity Level: Major)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Isocarboxazid				Dextroamphetamine
Mechanism 1		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Isocarboxazid and Dextroamphetamine
Increased risk of hyperpyrexia Click to Show/Hide Mechanism Graph
Drug Name		Isocarboxazid				Dextroamphetamine
Mechanism 2		Hyperpyrexia				Hyperpyrexia
Key Mechanism Factor 2
		Factor Name		Hyperpyrexia
		Factor Description		Hyperthermia is an extreme, life-threatening increase in core body temperature. If hyperthermia persists for a long time or worsens, more serious symptoms may occur, such as confusion, headache, constricted pupils, vomiting, diarrhea, and decreased urine output.
Mechanism Description		Increased risk of hyperpyrexia by the combination of Isocarboxazid and Dextroamphetamine

Recommended Action
Management		In general, CNS stimulants should not be used concurrently with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine).

References
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13	Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
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15	Product Information. Ritalin (methylphenidate). Novartis Pharmaceuticals, East Hanover, NJ.
16	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
17	Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
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