Drug General Information (ID: DDIIJXPH4M)
Drug Name			Bleomycin		Drug Info		Oxygen		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Nutritional Supplements
Structure

Mechanism of Bleomycin-Oxygen Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Bleomycin				Oxygen
Mechanism		Bleomycin				Increase the risk of bleomycin-associated respiratory distress syndrome
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Bleomycin and Oxygen

Recommended Action
Management		The manufacturer considers the use of pulmonary function tests with 100% oxygen to be contraindicated in bleomycin-treated patients, and recommends the use of pulmonary function tests with less than 21% oxygen. During general anesthesia, it is recommended that bleomycin-treated patients receive oxygen concentrations less than 30%.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".