Drug General Information (ID: DDIIDJ6O5P)
Drug Name			Guanethidine		Drug Info		Thiothixene		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antipsychotic Agents
Structure

Mechanism of Guanethidine-Thiothixene Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Guanethidine				Thiothixene
Mechanism		Guanethidine				Antagonize the hypotensive effect of guanethidine
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Guanethidine when combined with Thiothixene

Recommended Action
Management		Close blood pressure monitoring is recommended. Increased antihypertensive dosages may be necessary. alternative antihypertensive therapy may be considered.

References
1	Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9. [PMID: 7663034]
2	Janowsky DS, El-Yousef MK, Davis JM, Fann WE "Antagonism of guanethidine by chlorpromazine." Am J Psychiatry 130 (1973): 808-12
3	Gilder DA, Fain W, Simpson LL "A comparison of the abilities of chlorpromazine and molindone to interact adversely with guanethidine." J Pharmacol Exp Ther 198 (1976): 255-63