Drug General Information (ID: DDII9HXUP4)
Drug Name			Linezolid		Drug Info		Dezocine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Analgesics
Structure

Mechanism of Linezolid-Dezocine Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Linezolid				Dezocine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Linezolid and Dezocine

Recommended Action
Management		Narcotic analgesics should generally not be used with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with opioids.

References
1	Product Information. Emsam (selegiline). Bristol-Myers Squibb, Princeton, NJ.
2	Product Information. Tylenol with Codeine (acetaminophen-codeine). Janssen Pharmaceuticals, Raritan, NJ.
3	Zornberg GL, Hegarty JD "Adverse interaction between propoxyphene and phenelzine." Am J Psychiatry 150 (1993): 1270-1. [PMID: 8328578]