Drug General Information (ID: DDII8AFW7J)
Drug Name			Morphine (liposomal)		Drug Info		Isocarboxazid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antidepressants
Structure

Mechanism of Morphine (liposomal)-Isocarboxazid Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Morphine (liposomal)				Isocarboxazid
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Morphine (liposomal) and Isocarboxazid

Recommended Action
Management		Morphine liposomal preparations should not be used in patients taking MAOIs or other agents which possess MAOI activity (e.g., furazolidone, procarbazine, selegiline), or within 14 days of stopping such treatment.

References
1	Evans-Prosser CD "The use of pethidine and morphine in the presence of monoamine oxidase inhibitors." Br J Anaesth 40 (1968): 279-82. [PMID: 5654977]
2	Garbutt JC "Potentiation of propoxyphene by phenelzine." Am J Psychiatry 144 (1987): 251-2. [PMID: 2949636]
3	Zornberg GL, Hegarty JD "Adverse interaction between propoxyphene and phenelzine." Am J Psychiatry 150 (1993): 1270-1. [PMID: 8328578]