Details of Drug-Drug Interaction
| Drug General Information (ID: DDII3KD28E) | |||||||||
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| Drug Name | Valdecoxib | Drug Info | Plazomicin | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiinflammatory Agents | Aminoglycosides//Antibiotics | |||||||
| Structure | |||||||||
| Mechanism of Valdecoxib-Plazomicin Interaction (Severity Level: Moderate) | |||||||||
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| Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Valdecoxib | Plazomicin | |||||||
| Mechanism | Nephrotoxicity | Nephrotoxicity | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Nephrotoxicity | ||||||||
| Factor Description | The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Whenever feasible, NSAID use should preferably be discontinued prior to initiating IV aminoglycoside therapy. If concomitant administration is necessary, hydration status as well as renal and vestibular functions should be closely monitored. | ||||||||