Drug General Information (ID: DDIHXB2K4I)
Drug Name			Stavudine		Drug Info		Doxorubicin (liposomal)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antineoplastics
Structure

Mechanism of Stavudine-Doxorubicin (liposomal) Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Stavudine				Doxorubicin (liposomal)
Mechanism		Prodrug activated by intracellular phosphorylation				Intracellular phosphorylation inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Stavudine when combined with Doxorubicin (liposomal)

Recommended Action
Management		Monitoring for altered antiretroviral efficacy and HIV-RNA levels is advisable during concomitant administration.

References
1	Product Information. Zerit (stavudine). Bristol-Myers Squibb, Princeton, NJ.