Drug General Information (ID: DDIHRMO9LD)
Drug Name			Enoxacin		Drug Info		Phenyl salicylate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Salicylates
Structure

Mechanism of Enoxacin-Phenyl salicylate Interaction (Severity Level: Moderate)
Additive CNS stimulant effects Click to Show/Hide Mechanism Graph
Drug Name		Enoxacin				Phenyl salicylate
Mechanism		CNS stimulant effects				CNS stimulant effects
Key Mechanism Factor 1
		Factor Name		CNS stimulant effects
		Factor Description		CNS stimulants are drugs that stimulate the brain and can speed up mental and physical processes. Excessive CNS stimulation may lead to decreased appetite, increased heart rate, increased blood pressure, increased body temperature, convulsions, and seizures.
Mechanism Description		Additive CNS stimulant effects by the combination of Enoxacin and Phenyl salicylate

Recommended Action
Management		Clinical monitoring for signs of CNS stimulation such as tremors, involuntary muscle movements, hallucinations, or seizures is recommended if fluoroquinolone antibiotics are prescribed in combination with NSAIDs.

References
1	Davey PG "Overview of drug interactions with the quinolones." J Antimicrob Chemother 22(suppl c) (1988): 97-107. [PMID: 3053579]
2	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
3	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.