Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIHRE6NX5)
  Drug Name Prochlorperazine Drug Info Guanethidine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antipsychotic Agents Antihypertensive Agents
  Structure

 Mechanism of Prochlorperazine-Guanethidine Interaction (Severity Level: Moderate)
     Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Prochlorperazine Guanethidine
      Mechanism Inhibit the antihypertensive effect of postganglionic adrenergic blocking agent Antihypertensive agent
Noradrenaline transporter  Inducer
      Key Mechanism Factor 1
Factor Name Norepinephrine transporter
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Structure Sequence
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
Gene Name SLC6A2
Uniprot ID SC6A2_HUMAN
KEGG Pathway hsa:6530
Protein Family Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
Protein Function
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Prochlorperazine when combined with Guanethidine 

Recommended Action
      Management This combination should generally be avoided. An alternative antihypertensive regimen may be necessary for patients who must take phenothiazine antipsychotics. If patients do receive a phenothiazine with an adrenergic neurone blocker, their blood pressure should be monitored closely. The dosage of the antihypertensive may require adjustment.

References
1 Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9. [PMID: 7663034]
2 Gilder DA, Fain W, Simpson LL "A comparison of the abilities of chlorpromazine and molindone to interact adversely with guanethidine." J Pharmacol Exp Ther 198 (1976): 255-63
3 Fann WE, Janowsky DS, Davis JM, Oates JA "Chlorpromazine reversal of the antihypertensive action of guanethidine." Lancet 2 (1971): 436-7