Drug General Information (ID: DDIHN6O43V)
Drug Name			Pantoprazole		Drug Info		Vismodegib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antineoplastics/Hedgehog Pathway Inhibitors
Structure

Mechanism of Pantoprazole-Vismodegib Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Pantoprazole				Vismodegib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Vismodegib due to altered gastric pH caused by Pantoprazole

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Erivedge (vismodegib). Genentech, South San Francisco, CA.