Drug General Information (ID: DDIHLRA9W1)
Drug Name			Cyclosporine		Drug Info		Octreotide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Somatostatin/Somatostatin Analogs
Structure

Mechanism of Cyclosporine-Octreotide Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Octreotide
Mechanism		Absorption decreased by somatostatin analogs				Somatostatin analog
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Cyclosporine caused by Octreotide

Recommended Action
Management		Pharmacologic effects and blood concentrations of cyclosporine should be monitored more closely whenever a somatostatin analog is added to or withdrawn from the patient's anti-rejection regimen, and the cyclosporine dosage adjusted as necessary. "

References
1	Landgraf R, Landgraf-Leurs MM, Nusser J, et al "Effect of somatostatin analogue (SMS201-995) on cyclosporine levels." Transplantation 44 (1987): 724-5. [PMID: 2891211]
2	Product Information. Neoral Oral Solution (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
3	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
4	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.