Drug General Information (ID: DDIHFO1SRA)
Drug Name			Butalbital		Drug Info		Benzatropine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antiparkinson Agents
Structure

Mechanism of Butalbital-Benzatropine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Butalbital				Benzatropine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Butalbital and Benzatropine

Recommended Action
Management		Patients taking central anticholinergic agents in combination with other CNS depressants should be monitored for potentially excessive or prolonged CNS depression, especially if they are elderly or debilitated. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness.

References
1	Product Information. Artane (trihexyphenidyl). Lederle Laboratories, Wayne, NJ.