Drug General Information (ID: DDIHE0L4BO)
Drug Name			Hydrochlorothiazide		Drug Info		Teriparatide		Drug Info
Drug Type		Small molecule				Protein/peptide
Therapeutic Class		Diuretics				Bone Density Conservation Agents
Structure

Mechanism of Hydrochlorothiazide-Teriparatide Interaction (Severity Level: Minor)
Increased risk of hypercalcemia Click to Show/Hide Mechanism Graph
Drug Name		Hydrochlorothiazide				Teriparatide
Mechanism		Hypercalcemia				Hypercalcemia
Key Mechanism Factor 1
		Factor Name		Hypercalcemia
		Factor Description		Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work.
Mechanism Description		Increased risk of hypercalcemia by the combination of Hydrochlorothiazide and Teriparatide

References
1	Tapaninen T, Neuvonen PJ, Niemi M "Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren." Clin Pharmacol Ther 88 (2010): 339-42. [PMID: 20664534]
2	Vaidyanathan S, Jarugula V, Dieterich HA, Howard D, Dole WP "Clinical pharmacokinetics and pharmacodynamics of aliskiren." Clin Pharmacokinet 47 (2008): 515-31. [PMID: 18611061]
3	Product Information. Forteo (teriparatide). Lilly, Eli and Company, Indianapolis, IN.