Drug General Information (ID: DDIHANJV4B)
Drug Name			Acarbose		Drug Info		Digoxin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Antiarrhythmic Agents
Structure

Mechanism of Acarbose-Digoxin Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Acarbose				Digoxin
Mechanism		Acarbose				Adsorbed by acarbose
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Digoxin due to adsorption of Acarbose

Recommended Action
Management		Pharmacologic response and digoxin plasma levels should be monitored more closely following initiation or discontinuation of acarbose, and the digoxin dosage adjusted as necessary. Patients should be advised to notify their physician if they experience worsening of their heart symptoms.

References
1	Product Information. Precose (acarbose). Bayer, West Haven, CT.
2	Serrano JS, Jimenez CM, Serrano MI, Balboa B "A possible interaction of potential clinical interest between digoxin and acarbose." Clin Pharmacol Ther 60 (1996): 589-92. [PMID: 8941033]