Drug General Information (ID: DDIH8X0JTE)
Drug Name			Lumateperone		Drug Info		Ioflupane I-123		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Atypical Antipsychotics				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Lumateperone-Ioflupane I-123 Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Lumateperone				Ioflupane I-123
Mechanism		Interference with the diagnosis of Ioflupane I-123				Ioflupane I-123
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Ioflupane I-123 by Lumateperone

Recommended Action
Management		Clinicians using ioflupane I-123 should be aware of possible diagnostic interference by dopamine agonists and antagonists.

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Product Information. DaTscan (ioflupane I-123). GE Healthcare, Princeton, NJ.