Drug General Information (ID: DDIH84WSAP)
Drug Name			Pantoprazole		Drug Info		Naproxen		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Nsaids/Analgesics
Structure

Mechanism of Pantoprazole-Naproxen Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Pantoprazole				Naproxen
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Naproxen due to altered gastric pH caused by Pantoprazole

Recommended Action
Management		Concomitant use of these drugs is generally not recommended.

References
1	Product Information. Naprosyn (naproxen). Syntex Laboratories Inc, Palo Alto, CA.