Drug General Information (ID: DDIH7DLZAX)
  Drug Name Phentolamine Drug Info Insulin glulisine Drug Info
  Drug Type Small molecule Hormones
  Therapeutic Class Antihypertensive Agents Antidiabetic Agents
  Structure

 Mechanism of Phentolamine-Insulin glulisine Interaction (Severity Level: Minor)
     Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Phentolamine Insulin glulisine
      Mechanism Hypoglycemic effects
Increase the endogenous secretion of insulin 
Insulin
      Key Mechanism Factor 1
Factor Name Hypoglycemia
Factor Description Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
      Mechanism Description
  • Increased risk of hypoglycemia by the combination of Phentolamine and Insulin glulisine 

References
1 Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
2 Persson I, Larsen L "Serum insulin concentration after alpha-adrenergic blockade and secretin in diabetics." Acta Endocrinol (Copenh) 71 (1972): 331-7
3 Linde J, Deckert T "Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion." Horm Metab Res 5 (1973): 391-5