Drug General Information (ID: DDIH13G4UP)
Drug Name			Vancomycin		Drug Info		Netilmicin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Antibiotics
Structure

Mechanism of Vancomycin-Netilmicin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Vancomycin				Netilmicin
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Vancomycin and Netilmicin

Recommended Action
Management		If these drugs must be used together, renal function and serum drug concentrations should be monitored.

References
1	Dean RP, Wagner DJ, Tolpin MD "Vancomycin/aminoglycoside nephrotoxicity." J Pediatr 106 (1985): 861-2. [PMID: 3998936]
2	Downs NJ, Neihart RE, Dolezal JM, Hodges GR "Mild nephrotoxicity associated with vancomycin use." Arch Intern Med 149 (1989): 1777-81. [PMID: 2764651]
3	Farber BF, Moellering RC Jr "Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981." Antimicrob Agents Chemother 23 (1983): 138-41. [PMID: 6219616]
4	Odio C, McCracken GH, Nelson JD "Nephrotoxicity associated with vancomycin-aminoglycoside therapy in four children." J Pediatr 105 (1984): 491-2. [PMID: 6470874]
5	Pauly DJ, Musa DM, Lestico MR, Lindstrom MJ, Hetsko CM "Risk of nephrotoxicity with combination vancomycin-aminoglycoside antibiotic therapy." Pharmacotherapy 10 (1990): 378-82. [PMID: 2287556]
6	Sorrell TC, Collignon PJ "A prospective study of adverse reactions associated with vancomycin therapy." J Antimicrob Chemother 16 (1985): 235-41. [PMID: 3934126]