Drug General Information (ID: DDIGVH7XIK)
Drug Name			Carbamazepine		Drug Info		Adenosine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants/Antimanic Agents				Antiarrhythmic Agents
Structure

Mechanism of Carbamazepine-Adenosine Interaction (Severity Level: Moderate)
Increased risk of atrioventricular block Click to Show/Hide Mechanism Graph
Drug Name		Carbamazepine				Adenosine
Mechanism		Delay atrioventricular conduction				Delay atrioventricular conduction
Key Mechanism Factor 1
		Factor Name		Atrioventricular block
		Factor Description		Atrioventricular block is a type of cardiac conduction block that occurs when the electrical signal from the atria to the ventricles is impaired. In an Atrioventricular block, this electrical signal is either delayed or completely blocked. When the signal is completely blocked, the ventricles produce their own electrical signal to control the heart rate. The heart rate produced by the ventricles is much slower than that produced by the sinus node.
Mechanism Description		Increased risk of atrioventricular block by the combination of Carbamazepine and Adenosine

Recommended Action
Management		Electrocardiographic rhythm monitoring and monitoring for increased cardiovascular toxicity are recommended during coadministration.

References
1	Garg SK, Kumar N, Bhargava VK, Prabhakar SK "Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy." Clin Pharmacol Ther 64 (1998): 286-8. [PMID: 9757152]
2	Product Information. Adenocard (adenosine). Fujisawa, Deerfield, IL.
3	Fujiwara Y, Sato M, Otsuki S "Interaction of carbamazepine and other drugs with adenosine (A1 and A2) receptors." Psychopharmacology (Berl) 90 (1986): 332-5