Drug General Information (ID: DDIGSCXQ5V)
Drug Name			Glipizide		Drug Info		Ertugliflozin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Antidiabetic Agents
Structure

Mechanism of Glipizide-Ertugliflozin Interaction (Severity Level: Moderate)
Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Drug Name		Glipizide				Ertugliflozin
Mechanism		Hypoglycemic effects				Hypoglycemic effects
Key Mechanism Factor 1
		Factor Name		Hypoglycemia
		Factor Description		Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
Mechanism Description		Increased risk of hypoglycemia by the combination of Glipizide and Ertugliflozin

Recommended Action
Management		A lower dosage of the insulin secretagogue or insulin may be required when used in combination with an SGLT-2 inhibitor.

References
1	Product Information. Invokana (canagliflozin). Janssen Pharmaceuticals, Titusville, NJ.
2	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
3	Product Information. Steglatro (ertugliflozin). Merck &amp Company Inc, Whitehouse Station, NJ.