Drug General Information (ID: DDIGQFL89M)
Drug Name			Digoxin		Drug Info		Levosalbutamol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Adrenergic Bronchodilators
Structure

Mechanism of Digoxin-Levosalbutamol Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Digoxin				Levosalbutamol
Mechanism		Digoxin				Increase distribution of digoxin to skeletal muscle
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Digoxin by Levosalbutamol

Recommended Action
Management		Caution is advised if albuterol is used concomitantly with digoxin. Monitoring of serum digoxin and potassium concentrations may be required. Clinical monitoring for digoxin toxicity and/or hypokalemia, particularly in patients at risk of hypokalemia should also be considered. Dosage adjustments for either medication may also be required whenever digoxin and albuterol are used concurrently. Patients should be advised to seek immediate medical attention if they experience signs of arrhythmias, such as sudden dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeats.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
3	Product Information. Ventolin (albuterol). Glaxo Wellcome, Research Triangle Park, NC.