Drug General Information (ID: DDIGPI68ZR)
Drug Name			Niraparib		Drug Info		Isatuximab		Drug Info
Drug Type		Small molecule				Monoclonal antibody
Therapeutic Class		Poly (Adp-Ribose) Polymerase Inhibitors				Antineoplastics/Cd38 Monoclonal Antibodies

Mechanism of Niraparib-Isatuximab Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Niraparib				Isatuximab
Mechanism		Myelosuppressive effects				Myelosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Niraparib and Isatuximab

Recommended Action
Management		Caution is advised if niraparib is prescribed with other myelosuppressive agents.

References
1	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.