Drug General Information (ID: DDIGOIC0XR)
Drug Name			Vincristine		Drug Info		Verapamil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Analgesics
Structure

Mechanism of Vincristine-Verapamil Interaction (Severity Level: Minor)
Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph
Drug Name		Vincristine				Verapamil
Mechanism		Competition for plasma protein binding sites				Competition for plasma protein binding sites
Key Mechanism Factor 1
		Factor Name		Plasma protein binding
		Factor Description		Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs.
Mechanism Description		Increased plasma concentration of Verapamil and Vincristine due to competitive binding of plasma proteins

References
1	Abdel-Rahman M, Wosch F, Harder S, Woodcock BG "Interaction between verapamil and vincristine binding to plasma proteins." Int J Clin Pharmacol Ther Toxicol 30 (1992): 536-7. [PMID: 1490822]