Drug General Information (ID: DDIGO7D48F)
Drug Name			Doxycycline		Drug Info		Benzylpenicillin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antibiotics
Structure

Mechanism of Doxycycline-Benzylpenicillin Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Doxycycline				Benzylpenicillin
Mechanism		Bacteriostatic agent Change actively growing bacteria into static ones				Bactericidal agent Bactericidal activity requires bacterial growth
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Doxycycline when combined with Benzylpenicillin

Recommended Action
Management		This combination should be avoided if possible.

References
1	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
2	Jawetz E "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med 123 (1975): 87-91
3	Olsson RA, Kirby JC, Romansky MJ "Pneumococcal meningitis in the adult." Ann Intern Med 55 (1961): 545-9