Drug General Information (ID: DDIGN86EX9)
Drug Name			Phenoxymethylpenicillin		Drug Info		Neomycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antibiotics
Structure

Mechanism of Phenoxymethylpenicillin-Neomycin Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Phenoxymethylpenicillin				Neomycin
Mechanism		Absorption affected by oral aminoglycosides-induced malabsorption				Malabsorption
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Phenoxymethylpenicillin caused by Neomycin

Recommended Action
Management		It may be advisable to monitor patients for reduced penicillin efficacy, consider a different oral antibiotic, or consider administering parenteral penicillin.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".