Drug General Information (ID: DDIGERVPYO)
Drug Name			Levothyroxine		Drug Info		Oxtriphylline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antithyroid Agents				Bronchodilators
Structure

Mechanism of Levothyroxine-Oxtriphylline Interaction (Severity Level: Moderate)
Increased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Levothyroxine				Oxtriphylline
Mechanism		Increase the metabolism of theophylline by improving thyroid function in patients with hypothyroidism				Theophylline
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased metabolism of Oxtriphylline caused by Levothyroxine

Recommended Action
Management		When thyroid hormone dosage is instituted, discontinued, or changed, close observation for altered theophylline effect and serum concentrations is recommended. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms, or any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeats.

References
1	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
2	Vozeh S, Otten M, Staub JJ, Follath F "Influence of thyroid function on theophylline kinetics." Clin Pharmacol Ther 36 (1984): 634-40
3	Bauman JH, Teichman S, Wible DA "Increased theophylline clearance in a patient with hyperthyroidism." Ann Allergy 52 (1984): 94-6