Drug General Information (ID: DDIG37E4XR)
Drug Name			Nilotinib		Drug Info		Magnesium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antacids
Structure

Mechanism of Nilotinib-Magnesium carbonate Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Nilotinib				Magnesium carbonate
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Nilotinib due to altered gastric pH caused by Magnesium carbonate

Recommended Action
Management		Patients treated with nilotinib should not take antacids or other agents with acid-neutralizing effects for at least 2 hours before or 2 hours after a nilotinib dose.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".