Drug General Information (ID: DDIFTC7QB3)
Drug Name			Clorazepic acid		Drug Info		Amiodarone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Antiarrhythmic Agents
Structure

Mechanism of Clorazepic acid-Amiodarone Interaction (Severity Level: Minor)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Clorazepic acid				Amiodarone
Mechanism 1		Benzodiazepines				Increase the pharmacologic effects of benzodiazepines
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Clorazepic acid and Amiodarone
Mechanism 2		Benzodiazepine				Increase the pharmacologic effects of benzodiazepines
Key Mechanism Factor 2
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Clorazepic acid and Amiodarone

References
1	Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23. [PMID: 2661600]
2	Nolan PE, Marcus FI, Karol MD, Hoyer GL, Gear K "Effect of phenytoin on the clinical pharmacokinetics of amiodarone." J Clin Pharmacol 30 (1990): 1112-9. [PMID: 2273084]
3	Product Information. Xanax XR (alprazolam). Pfizer U.S. Pharmaceuticals Group, New York, NY.