Details of Drug-Drug Interaction
| Drug General Information (ID: DDIFPGJQH5) | |||||||||
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| Drug Name | Colistimethate | Drug Info | Vecuronium | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antibiotics | Analgesics | |||||||
| Structure | |||||||||
| Mechanism of Colistimethate-Vecuronium Interaction (Severity Level: Major) | |||||||||
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| Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Colistimethate | Vecuronium | |||||||
| Mechanism | Neuromuscular blocking effects |
Neuromuscular blocking agent Neuronal acetylcholine receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Neuronal acetylcholine receptor | Structure Sequence | |||||||
| Protein Family | Ligand-gated ion channel (TC 1.A.9) family | ||||||||
| Protein Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Patients should be closely monitored for prolonged neuromuscular blockade. Intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases. | ||||||||