Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIFLAG36P)
  Drug Name Benzatropine Drug Info Propantheline Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiparkinson Agents Antispasmodics
  Structure

 Mechanism of Benzatropine-Propantheline Interaction (Severity Level: Moderate)
     Additive anticholinergic effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Benzatropine Propantheline
      Mechanism Anticholinergic effects
Muscarinic acetylcholine receptor  Antagonist 		Anticholinergic effects
Muscarinic acetylcholine receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Muscarinic acetylcholine receptor M Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
    Click to Show/Hide
      Mechanism Description
  • Additive anticholinergic effects by the combination of Benzatropine and Propantheline 

Recommended Action
      Management Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations.

References
1 Kulik AV, Wilbur R "Delirium and stereotypy from anticholinergic antiparkinson drugs." Prog Neuropsychopharmacol Biol Psychiatry 6 (1982): 75-82. [PMID: 7202232]
2 Mann SC, Boger WP "Psychotropic drugs, summer heat and humidity, and hyperplexia: a danger restated." Am J Psychiatry 135 (1978): 1097-100. [PMID: 29501]
3 Warnes H, Lehmann HE, Ban TA "Adynamic ileus during psychoactive medication: a report of three fatal and five severe cases." Can Med Assoc J 96 (1967): 1112-3. [PMID: 6021058]