Drug General Information (ID: DDIFKLU6HG)
Drug Name			Valaciclovir		Drug Info		Plazomicin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Aminoglycosides//Antibiotics
Structure

Mechanism of Valaciclovir-Plazomicin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Valaciclovir				Plazomicin
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Valaciclovir and Plazomicin

Recommended Action
Management		Close clinical and laboratory monitoring of renal function and drug serum concentrations (if clinically appropriate) is recommended.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Valtrex (valacyclovir). Glaxo Wellcome, Research Triangle Park, NC.