Drug General Information (ID: DDIFGCK10E)
Drug Name			Hydroxychloroquine		Drug Info		Remdesivir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimalarial Agents				Purine Nucleosides
Structure

Mechanism of Hydroxychloroquine-Remdesivir Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Hydroxychloroquine				Remdesivir
Mechanism		Antagonistic effects on intracellular metabolic activation and antiviral activity of remdesivir				Remdesivir
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Remdesivir when combined with Hydroxychloroquine

Recommended Action
Management		Due to antagonism observed in vitro, concomitant use of remdesivir with chloroquine phosphate or hydroxychloroquine sulfate is not recommended.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)."