Details of Drug-Drug Interaction
| Drug General Information (ID: DDIFEHPKQ6) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Glimepiride | Drug Info | Amitriptyline | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antidiabetic Agents | Analgesics | |||||||
| Structure | |||||||||
| Mechanism of Glimepiride-Amitriptyline Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Glimepiride | Amitriptyline | |||||||
| Mechanism |
Antidiabetic agent Sulfonylureas |
Increase the hypoglycemic effects of sulfonylureas | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Hypoglycemia | ||||||||
| Factor Description | Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Patients receiving this combination should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients. | ||||||||