Drug General Information (ID: DDIFADMOK5)
Drug Name			Digitoxin		Drug Info		Teriparatide		Drug Info
Drug Type		Small molecule				Protein/peptide
Therapeutic Class		Antiarrhythmic Agents				Bone Density Conservation Agents
Structure

Mechanism of Digitoxin-Teriparatide Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digitoxin				Teriparatide
Mechanism		Digitalis glycosides				Potentiate the risk of digitalis toxicity
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Digitoxin and Teriparatide

Recommended Action
Management		Caution is recommended during concomitant use of digitalis and human parathyroid hormone analogs. Serum calcium and digitalis levels should be closely monitored, and the digitalis dosage adjusted as necessary. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

References
1	Product Information. Forteo (teriparatide). Lilly, Eli and Company, Indianapolis, IN.
2	Benson CT, Voelker JR "Teriparatide has no effect on the calcium-mediated pharmacodynamics of digoxin." Clin Pharmacol Ther 73 (2003): 87-94. [PMID: 12545147]