Drug General Information (ID: DDIF8TYO5D)
Drug Name			Measles virus vaccine live attenuated		Drug Info		Tuberculin purified protein derivative		Drug Info
Drug Type		Vaccine				Allergenics
Therapeutic Class		Vaccine				Allergy Test

Mechanism of Measles virus vaccine live attenuated-Tuberculin purified protein derivative Interaction (Severity Level: Moderate)
Diminish the response to diagnostic skin test antigens Click to Show/Hide Mechanism Graph
Drug Name		Measles virus vaccine live attenuated				Tuberculin purified protein derivative
Mechanism		Vaccine or toxoid				Diagnostic skin test antigens
Key Mechanism Factor 1
		Factor Name		Diagnostic skin test antigens
		Factor Description		The efficacy of diagnostic skin test antigens may be reduced, leading to falsely insignificant or false-negative results may occur in such patients.
Mechanism Description		Reduced reactions to diagnostic skin test antigens for Tuberculin purified protein derivative when combined with Measles virus vaccine live attenuated

Recommended Action
Management		Clinicians should be aware of the potential for falsely insignificant or false-negative results when performing delayed-hypersensitivity skin testing on patients who have recently received live virus vaccines. Diagnostic skin test antigens should be administered before, simultaneously with, or 4 to 6 weeks after immunization.

References
1	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
2	Product Information. Multitest CMI (skin test antigens, multiple). Aventis Pharmaceuticals, Swiftwater, PA.
3	Product Information. MSTA Mumps Skin Test Antigen (mumps skin test antigen). Aventis Pharmaceuticals, Swiftwater, PA.