Drug General Information (ID: DDIF6P2HAS)
Drug Name			Trospium		Drug Info		Ranitidine (bismuth citrate)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Parasympatholytics				Antiulcer Agents
Structure

Mechanism of Trospium-Ranitidine (bismuth citrate) Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Trospium				Ranitidine (bismuth citrate)
Mechanism		Trospium				Competitive inhibition of renal tubular secretion of trospium
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Trospium caused by Ranitidine (bismuth citrate) mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Patients receiving trospium chloride in combination with other drugs that undergo active tubular secretion should be monitored for excessive pharmacologic effects of one or both drugs, and the dosages of the drugs adjusted if necessary.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Canadian Pharmacists Association "e-CPS."
3	Product Information. Sanctura (trospium chloride). Odyssey Pharmaceutical, East Hanover, NJ.