Drug General Information (ID: DDIEZATN8J)
Drug Name			Oxytetracycline		Drug Info		Zinc chloride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Minerals And Electrolytes
Structure

Mechanism of Oxytetracycline-Zinc chloride Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Oxytetracycline				Zinc chloride
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Zinc chloride due to formation of complexes caused by Oxytetracycline

Recommended Action
Management		Patients receiving an oral tetracycline in combination with zinc-containing products should be advised to separate the times of administration by at least three to four hours. Doxycycline may be an appropriate alternative, since its absorption may not be significantly affected by zinc coadministration.

References
1	Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54. [PMID: 946598]
2	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
3	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.