Drug General Information (ID: DDIETK08A4)
Drug Name			Chlorpropamide		Drug Info		Sodium acetate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Minerals And Electrolytes
Structure

Mechanism of Chlorpropamide-Sodium acetate Interaction (Severity Level: Minor)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Chlorpropamide				Sodium acetate
Mechanism		Urine pH sensitive				Urine alkalinizer
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Chlorpropamide caused by Sodium acetate mediated altered urine pH

References
1	Kivisto KT, Neuvonen PJ "Differential effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide." Eur J Clin Pharmacol 40 (1991): 383-6. [PMID: 1646724]
2	Neuvonen PJ, Karkkainen S "Effects of charcoal, sodium bicarbonate, and ammonium chloride on chlorpropamide kinetics." Clin Pharmacol Ther 33 (1983): 386-93. [PMID: 6297841]