Drug General Information (ID: DDIEJS5HKP)
Drug Name			Etanercept		Drug Info		Anakinra		Drug Info
Drug Type		Monoclonal antibody				Interferons
Therapeutic Class		Antirheumatics				Antiinflammatory Agents

Mechanism of Etanercept-Anakinra Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Etanercept				Anakinra
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Etanercept and Anakinra

Recommended Action
Management		Concomitant use of an IL-1 blocker and a TNF blocker is not recommended.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
3	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
4	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
5	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
6	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.