Drug General Information (ID: DDIEIUXS3M)
Drug Name			Orlistat		Drug Info		Triheptanoin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiobesity Agents				Nutritional Supplements
Structure

Mechanism of Orlistat-Triheptanoin Interaction (Severity Level: Major)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Orlistat				Triheptanoin
Mechanism		Orlistat				Absorption possibly altered by orlistat
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Triheptanoin caused by Orlistat

Recommended Action
Management		Coadministration of triheptanoin with a pancreatic lipase inhibitor, such as orlistat, should be avoided.

References
1	Product Information. Dojolvi (triheptanoin). Ultragenyx Pharmaceutical, Novato, CA.