Drug General Information (ID: DDIEH3TVBU)
Drug Name			Levothyroxine		Drug Info		Labetalol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antithyroid Agents				Antihypertensive Agents
Structure

Mechanism of Levothyroxine-Labetalol Interaction (Severity Level: Minor)
Increased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Levothyroxine				Labetalol
Mechanism		Increase in hepatic metabolism of beta blocker by reversing decreased hepatic blood flow associated with hypothyroidism Increase in hepatic metabolism of beta-blocker by reversing decreased hepatic blood flow associated with hypothyroidism				Beta blocker
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased metabolism of Labetalol caused by Levothyroxine

References
1	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
2	Aro A, Antila M, Korhonen T, Sundquist H "Pharmacokinetics of propranolol and sotalol in hyperthyroidism." Eur J Clin Pharmacol 21 (1982): 373-7
3	Wells PG, Feely J, Wilkinson GR, Wood AJ "Effect of thyrotoxicosis on liver blood flow and propranolol disposition after long-term dosing." Clin Pharmacol Ther 33 (1983): 603-8