Details of Drug-Drug Interaction
| Drug General Information (ID: DDIEGOZD8H) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Rifampicin | Drug Info | Cefamandole | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antituberculosis Agents | Antibiotics | |||||||
| Structure | |||||||||
| Mechanism of Rifampicin-Cefamandole Interaction (Severity Level: Major) | |||||||||
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| Increased risk of bleeding Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Rifampicin | Cefamandole | |||||||
| Mechanism | Risk of bleeding | Risk of bleeding | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Bleeding | ||||||||
| Factor Description | Patients may be at risk for bleeding when the outcome of a disease or disease treatment confounds the standard mechanisms for maintaining hemostasis. Signs or symptoms of abnormal bleeding include: bleeding that takes a long time to stop (including nosebleeds, bleeding gums, bleeding from cuts and abrasions, and menstrual bleeding); severe unexplained bruising, or bruising that becomes larger; blood in the urine or stool, etc. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | The concomitant use of rifampin with other antibiotics which cause vitamin K dependent coagulopathy, such as cephalosporins, should be avoided. If coadministration is unavoidable, monitoring of prothrombin time and INR should be considered and the patient should be observed for signs of bleeding. Patients should be advised to notify their physicians if they experience any signs or symptoms that may indicate excessive anticoagulation, such as unusual or prolonged bleeding, bruising, coffee ground emesis, change in stool or urine color, headache, dizziness, or weakness. | ||||||||