Drug General Information (ID: DDIEA5JK0B)
  Drug Name Gemtuzumab ozogamicin Drug Info Enoxacin Drug Info
  Drug Type Monoclonal antibody Small molecule
  Therapeutic Class Antineoplastics Antiinfective Agents

 Mechanism of Gemtuzumab ozogamicin-Enoxacin Interaction (Severity Level: Minor)
     Altered intestinal mucosa Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Gemtuzumab ozogamicin Enoxacin
      Mechanism Alteration of intestinal mucosa Absorption affected by changes in intestinal mucosa
      Key Mechanism Factor 1
Factor Name Intestinal mucosa
Factor Description Intestinal mucosal barrier function is the ability of the intestine to adequately contain microorganisms and molecules in the lumen while maintaining the ability to absorb nutrients. The absorption of drugs may be altered when the intestinal mucosa is disrupted.
      Mechanism Description
  • Decreased absorption of Enoxacin due to intestinal mucosa variation caused by Gemtuzumab ozogamicin 

References
1 Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]