Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIE9PWG8Y)
  Drug Name Ranitidine Drug Info Doxacurium Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiulcer Agents Analgesics
  Structure

 Mechanism of Ranitidine-Doxacurium Interaction (Severity Level: Minor)
     Antagonize the effect of neuromuscular blocking agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Ranitidine Doxacurium
      Mechanism Attenuates neuromuscular blockade Neuromuscular blocking agent
Neuronal acetylcholine receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Doxacurium when combined with Ranitidine 

References
1 Katende RS, Dimich I "Resistance to nondepolarizing muscle relaxants in a patient treated with ranitidine." Mt Sinai J Med 54 (1987): 330-1. [PMID: 2955219]
2 McCarthy G, Mirakhur RK, Elliott P, Wright J "Effect of H2-receptor antagonist pretreatment on vecuronium- and atracurium-induced neuromuscular block." Br J Anaesth 66 (1991): 713-5. [PMID: 1676594]
3 Woodworth GE, Sears DH, Grove TM, et al "The effect of cimetidine and ranitidine on the duration of action of succinylcholine." Anesth Analg 68 (1989): 295-7. [PMID: 2919769]