Drug General Information (ID: DDIE7VP2KT)
Drug Name			Diazoxide		Drug Info		Polythiazide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antihypertensive Agents
Structure

Mechanism of Diazoxide-Polythiazide Interaction (Severity Level: Moderate)
Increased risk of hyperglycemia Click to Show/Hide Mechanism Graph
Drug Name		Diazoxide				Polythiazide
Mechanism 1		Hyperglycemia				Hyperglycemia
Key Mechanism Factor 1
		Factor Name		Hyperglycemia
		Factor Description		Drugs can induce hyperglycemia through a variety of mechanisms, including altered insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells, and increased glucose production. Hyperglycemia may increase the risk of microvascular and macrovascular complications, infection, metabolic coma and even death.
Mechanism Description		Increased risk of hyperglycemia by the combination of Diazoxide and Polythiazide
Mechanism 2		Hyperglycemic effects				Hyperglycemia
Key Mechanism Factor 2
		Factor Name		Hyperglycemia
		Factor Description		Drugs can induce hyperglycemia through a variety of mechanisms, including altered insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells, and increased glucose production. Hyperglycemia may increase the risk of microvascular and macrovascular complications, infection, metabolic coma and even death.
Mechanism Description		Increased risk of hyperglycemia by the combination of Diazoxide and Polythiazide
Mechanism 3		Hyperglycemia				Hyperglycemic effects
Key Mechanism Factor 3
		Factor Name		Hyperglycemia
		Factor Description		Drugs can induce hyperglycemia through a variety of mechanisms, including altered insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells, and increased glucose production. Hyperglycemia may increase the risk of microvascular and macrovascular complications, infection, metabolic coma and even death.
Mechanism Description		Increased risk of hyperglycemia by the combination of Diazoxide and Polythiazide
Mechanism 4		Hyperglycemic effects				Hyperglycemic effects
Key Mechanism Factor 4
		Factor Name		Hyperglycemia
		Factor Description		Drugs can induce hyperglycemia through a variety of mechanisms, including altered insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells, and increased glucose production. Hyperglycemia may increase the risk of microvascular and macrovascular complications, infection, metabolic coma and even death.
Mechanism Description		Increased risk of hyperglycemia by the combination of Diazoxide and Polythiazide

Recommended Action
Management		Blood glucose monitoring is recommended during coadministration.

References
1	Seltzer HS, Allen EW "Hyperglycemia and inhibition of insulin secretion during administration of diazoxide and trichlormethiazide in man." Diabetes 18 (1969): 19-28. [PMID: 5761863]