Drug General Information (ID: DDIDZ71S2Q)
Drug Name			Chloramphenicol		Drug Info		Oxacillin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antibiotics
Structure

Mechanism of Chloramphenicol-Oxacillin Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Chloramphenicol				Oxacillin
Mechanism		Bacteriostatic agent Change actively growing bacteria into static ones				Bactericidal agent Bactericidal activity requires bacterial growth
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Chloramphenicol when combined with Oxacillin

Recommended Action
Management		Until more information is available, this combination should probably be reserved for conditions where it has been found to be efficacious and avoided in situations where bactericidal activity is necessary, such as certain types of bacterial meningitis or staphylococcal endocarditis. If the combination is necessary, some experts recommend administering the penicillin several hours before the chloramphenicol. Patients should be closely monitored for altered antimicrobial efficacy.

References
1	Shalit I, Marks MI "Chloramphenicol in the 1980s." Drugs 28 (1984): 281-91
2	Jawetz E "The use of combinations of antimicrobial drugs." Annu Rev Pharmacol 8 (1968): 151
3	Wallace JF, Smith RH, Garcia M, Petersdorf RG "Studies on the pathogenesis of meningitis. VI: antagonism between penicillin and chloramphenicol in experimental pneumococcal meningitis." J Lab Clin Med 70 (1967): 408-18