Drug General Information (ID: DDIDXH1632)
Drug Name			Adalimumab		Drug Info		Canakinumab		Drug Info
Drug Type		Monoclonal antibody				Monoclonal antibody
Therapeutic Class		Antirheumatics				Interleukin Inhibitors

Mechanism of Adalimumab-Canakinumab Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Adalimumab				Canakinumab
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Adalimumab and Canakinumab

Recommended Action
Management		Concomitant use of an IL-1 blocker and a TNF blocker is not recommended.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
4	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
5	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
6	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
7	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
8	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.